Targeting transcription to suppress these anti apoptotic

Cancer cells depend heavily on sustained expression of anti apoptotic proteins. Targeting transcription to suppress these anti apoptotic proteins seems a promising strategy for anti cancer therapy. Cyclin dependant kinase 9 (CDK9) regulates transcription elongation by phosphorylating Ser2 on the C terminal domain of RNA polymerase II, while CDK7 phosphorylates Ser5 during transcription initiation.

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